Rapid induction of hypothyroidism by an avian leukosis virus

Rapid induction of hypothyroidism by an avian leukosis virus.

Infection of 10-day chicken embryos with an avian leukosis virus, RAV-7, resulted in hypothyroidism within 3 weeks posthatching. Histological examination of the thyroids from infected chickens showed an extensive infiltration of lymphoblastoid cells by 7 days posthatching. Areas resembling germinal centers were present in the thyroids of infected chickens by 3 weeks posthatching. Examination of...

Avian Leukosis Virus

Ultrastructural studies of chick embryo cells morphological ly altered by strain MC29 avian leukosis virus revealed marked and characteristic differences from normal cells and cells al tered by infection with other avian tumor viruses. Such differ ences were manifest in part in the cytoplasm by high content of free ribosomes, poorly developed rough endoplasmic reticu lum, frequent fat droplets,...

Genetic determinant of rapid-onset B-cell lymphoma by avian leukosis virus.

Infection of 10 day-old chicken embryos with the recombinant avian leukosis virus (ALV) EU-8 induces a high incidence of rapid-onset B-cell lymphoma by insertional activation of the c-myb gene. LR-9, a related ALV with differences from EU-8 in the gag and pol genes, induces rapid-onset lymphoma at only a low incidence. To localize the viral determinant(s) responsible for this biologic differenc...

Avian lymphoid leukosis: Virus-like particles in kidney Cells

Infection and Tumor Formation in Chickens By Avian Leukosis Virus

Lymphoid leukosis in chickens is a disease which arises from the result of complicated interaction between avian leukosis virus (ALV) as a pathogenic organism and chicken as a host. This report is intended to outline our present knowledge about genetic resistance of chickens in lymphoid leukosis. The defense of host in infectious disease could be considered dividing it into two: one as a workin...